clinical utility of indigenously formulated single-vial lyophilized hynic-toc kit in evaluating gastro-entero pancreatic neuro endocrine tumours

نویسندگان

ajit s shinto nuclear medicine department, kovai medical center and hospital, india

k. kamaleshwaran nuclear medicine department, kovai medical center and hospital, india

k vyshak nuclear medicine department, kovai medical center and hospital, india

natarajan sudhakar nuclear medicine department, kovai medical center and hospital, india

چکیده

objective(s): the objective of this study was to evaluate the performance and utility of 99mtc hynic-toc planar scintigraphy and spect/ct in the diagnosis, staging and management of gastroenteropancreatic neuroendocrine tumors (gpnets). methods: 22 patients (median age, 46 years) with histologically proven gastroentero-pancreatic nets underwent 99mtc hynic-toc whole body scintigraphy and regional spect/ct as indicated. scanning was performed after injection of 370-550 mbq (10-15 mci) of 99mtc hynic-toc intravenously. images were evaluated by two experienced nuclear medicine physicians both qualitatively as well as semi quantitatively (tumor to background and tumor to normal liver ratios on spect -ct images). results of spect/ct were compared with the results of conventional imaging. histopathology results and follow-up somatostatin receptor scintigraphy with 99mtc hynic toc or conventional imaging with biochemical markers were considered to be the reference standards. results: 99mtc hynic toc showed sensitivity and specificity of 87.5% and 85.7%, respectively, for primary tumor and 100% and 86% for metastases. it was better than conventional imaging modalities for the detection of both primary tumor (p<0.001) and metastases (p<0.0001). it changed the management strategy in 6 patients (31.8%) and supported management decisions in 8 patients (36.3%). conclusion: 99mtc hynic toc spect/ct appears to be a highly sensitive and specific modality for the detection and staging of gpnets. it is better than conventional imaging for the evaluation of gpnets and can have a significant impact on patient management and planning further therapeutic options.

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Clinical utility of indigenously formulated single-vial lyophilized HYNIC-TOC kit in evaluating Gastro-entero Pancreatic neuro endocrine tumours

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Clinical utility of indigenously formulated single-vial lyophilized HYNIC-TOC kit in evaluating Gastro-entero Pancreatic neuro endocrine tumours

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عنوان ژورنال:
asia oceania journal of nuclear medicine and biology

جلد ۲، شماره ۱، صفحات ۳۰-۴۱

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